Transgender people are targets of discrimination in many areas of their lives; this marginalization exposes them to tremendous social and economic insecurity. Until now, data on the prevalence and character of this discrimination has been limited to small studies and anecdotal reports. In the first comprehensive national effort to document this problem, the National Center for Transgender Equality and the National Gay and Lesbian Task Force launched a six-month data collection process, interviewing 6,450 transgender people via an extensive questionnaire that covered critical topics such as employment, education, health care, housing, public accommodation, criminal justice, family life and access to government documents. Our final sample included residents of all 50 states, Puerto Rico, Guam and the U.S. Virgin Islands. Data gathered from respondents was compared to US Census Bureau and Department of Labor data.